Clinical profile of cardiovascular diseases in pregnant women treated in a specialized clinic

Authors

Keywords:

Keywords: pregnancy, cardiovascular disease, hypertensive heart disease, maternal risk, perinatal outcome.

Abstract

Abstract

Introduction: Cardiovascular diseases during pregnancy are a relevant cause of maternal and perinatal morbidity and mortality, especially in women with pre-existing cardiovascular risk factors.

Objective: To describe the clinical-epidemiological profile and maternal-fetal outcomes in pregnant women with cardiovascular diseases.

Methods: An observational, descriptive, case-series study was conducted, including 91 pregnant women treated at the Cardiac Disease and Pregnancy Clinic of Carlos Manuel de Céspedes Hospital, Bayamo (Cuba), between 2022 and 2024. Demographic, clinical, echocardiographic, and perinatal variables were analyzed.

Results: The overall prevalence was 23.1 %. The mean age was 26.8 ± 6.7 years, with women ≤ 25 years representing 46.2 %. Comorbidities were present in 29.7 %, mainly hypertensive disorders of pregnancy (24.2 %) and chronic hypertension (9.9 %). Most patients were in NYHA functional class I  (86 %) with a mean ejection fraction of 63.4 ± 5.1 %. The main symptoms were palpitations (37.4 %), cardiac murmurs (28.6 %), and precordial pain (11.0 %). Electrocardiographic abnormalities were found in 66 %, predominantly sinus tachycardia (27.5 %) and right bundle branch block (8.8 %). The most frequent conditions were hypertensive heart disease (7.6 %), mitral valve prolapse (5.6 %), and atrial septal defect (3.2 %). According to the modified WHO classification, 57.1 % were class I and 19.0 % class II; 72.5 % received cardiovascular treatment. No maternal or fetal deaths occurred. The most common perinatal complications were low birth weight and preterm delivery.

Conclusions: Hypertensive heart disease and benign arrhythmias were the most frequent entities. Most patients had a favorable course, underscoring the importance of specialized monitoring and multidisciplinary care.

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Author Biographies

Julio César González Céspedes, Hospital Carlos Manuel de Céspedes

Especialista de I grado en Cardiología y en Medicina General Integral

Profesor asistente

Toilibou Taoufique, Hospital Carlos Manuel de Céspedes

Residente de tercer año de Cardiología. Especialista de I grado en Medicina General Integral

Luis Germán Ramírez Domínguez, Hospital Carlos Manuel de Céspedes

Especialista de I grado en Cardiología

Profesor asistente

Orlando Santiago Aguilar Almaguer, Hospital Carlos Manuel de Céspedes

Especialista de I grado en Cardiología y en Medicina General Integral

Profesor instructor

Alfredo Leyva Rodriguez, Hospital Carlos Manuel de Céspedes

Especialista de I grado en Cardiología y en Medicina General Integral

Profesor instructor

References

Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomström-Lundqvist C, Cífková R, De Bonis M, et al. Guías de la ESC 2018 para el manejo de las enfermedades cardiovasculares durante el embarazo. Eur Heart J. 2018; 39:3165–3241. https://doi.org/10.1093/eurheartj/ehy340

Iftikhar SF, Biswas M. Enfermedad cardíaca en el embarazo. [Actualizado el 10 de julio de 2023]. En: StatPearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; Ene 2025. Disponible en: https://www-ncbi-nlm-nih-gov.translate.goog/books/NBK537261/?_x_tr_sl=en&_x_tr_tl=es&_x_tr_hl=es&_x_tr_pto=tc

Bredy C, Deville F, Huguet H, Picot MC, De La Villeon G, Abassi H, et al. Which risk score best predicts cardiovascular outcome in pregnant women with congenital heart disease? Eur Heart J Qual Care Clin Outcomes. 2023; 9(2):177-183. DOI:10.1093/ehjqcco/qcac019

Roos-Hesselink J, Baris L, Johnson M, De Backer J, Otto C, Marelli, A, et al. Pregnancy outcomes in women with cardiovascular disease: evolving trends over 10 years in the ESC Registry Of Pregnancy And Cardiac disease (ROPAC). Eur Heart J. 2019;40(47):3848-3855. DOI:10.1093/eurheartj/ehz136

Mcilvaine S, Feinberg L, Spiel M. Cardiovascular Disease in Pregnancy. Neoreviews. 2021; 22(11):e747-e759. DOI:10.1542/neo.22-11-e747

Sharma G, Ying W, Silversides CK. The Importance of Cardiovascular Risk Assessment and Pregnancy Heart Team in the Management of Cardiovascular Disease in Pregnancy. Cardiol Clin. 2021;39(1):7-19. DOI: 10.1016/j.ccl.2020.09.002

Silversides CK, Grewal J, Mason J, Sermer M, Kiess M, Rychel V, et al. Pregnancy Outcomes in Women With Heart Disease: The CARPREG II Study. J Am Coll Cardiol. 2018; 71(21):2419-2430. DOI: 10.1016/j.jacc.2018.02.076

Kulasekaran A, SwanL. Pregnancy and Congenital Heart Disease: Moving Beyond the Current Risk Stratification Tools. US Cardiology Review 2023; 17: e06. DOI: https://doi.org/10.15420/usc.2022.16

Richardson M, Bonnet JP, Coulon C, Domanski O, Constans B, Estevez MG, et al. Management and outcomes of pregnant women with cardiovascular diseases in a cardio-obstetric team. Arch Cardiovasc Dis. 2024;117(5):343-350. DOI:10.1016/j.acvd.2024.02.009

Pfaller B, Sathananthan G, Grewal J, Mason J, D'Souza R, Spears D, et al. Preventing complications in pregnant women with cardiac disease. J Am Coll Cardiol. 2020;75(13):1443–1452. DOI: 10.1016/j.jacc.2020.01.039

Wander G, van der Zande JA, Patel RR, Johnson MR, Roos-Hesselink J. Pregnancy in women with congenital heart disease: a focus on management and preventing the risk of complications. Expert Rev Cardiovasc Ther. 2023; 21(8):587-599. DOI:10.1080/14779072.2023.2237886

Wolfe DS, Guerrero K. The contemporary cardio-obstetrics team: The path to improving maternal outcomes in high-risk patients. Am Heart J. 2025;281:140-148. DOI: 10.1016/j.ahj.2024.12.001

Sharma G, Ying W, Silversides CK. The Importance of Cardiovascular Risk Assessment and Pregnancy Heart Team in the Management of Cardiovascular Disease in Pregnancy. Cardiol Clin. 2021;39(1):7-19. DOI: 10.1016/j.ccl.2020.09.002

Aquieri A, Crosa V, Patiño I, Losada B, Vázquez Blanco M, Páez O, et al. Consenso de enfermedad cardiovascular y embarazo. Rev Argent Cardiol 2023;91 (Suplemento 8):1-172. http://dx.doi.org/10.7775/rac.es.v91.s8

Morton A. Physiological Changes and Cardiovascular Investigations in Pregnancy. Heart Lung Circ. 2021;30:e6–e15. DOI: 10.1016/j.hlc.2020.10.001

Das BB, Aggarwal V, Deshpande SR. Navigating women with congenital heart disease during pregnancy: Management strategies and future directions. World J Cardiol. 2025;17(6):106295. DOI:10.4330/wjc. v17.i6.106295

Lía-Crosa V, Aquieri A, Pineda V, et al. Embarazo y riesgo cardiovascular. Cardiovasc Metab Sci 2022;33(Suppl: 5):s434-438. DOI:10.35366/108046.

Tendencias de la mortalidad materna de 2000 a 2023: estimaciones de la OMS, el UNICEF, el UNFPA, el Grupo del Banco Mundial y la División de Población del DAES. [Internet] April 7 2025. [citado 25/07/2025]. Disponible en:

https://www-who-int.translate.goog/publications/i/item/9789240108462?_x_tr_sl=en&_x_tr_tl=es&_x_tr_hl=es&_x_tr_pto=tc

Windram J, Grewal J, Bottega N, Sermer M, Spears D, Swan L, et al. Canadian Cardiovascular Society: Clinical Practice Update on Cardiovascular Management of the Pregnant Patient. Can J Cardiol. 2021;37(12):1886-1901. DOI: 10.1016/j.cjca.2021.06.021

D'Souza RD, Silversides CK, Tomlinson GA, Siu SC. Assessing Cardiac Risk in Pregnant Women With Heart Disease: How Risk Scores Are Created and Their Role in Clinical Practice. Can J Cardiol. 2020; 36(7):1011-1021. DOI: 10.1016/j.cjca.2020.02.079

Published

2025-10-17

How to Cite

1.
González Céspedes JC, Taoufique T, Ramírez Domínguez LG, Aguilar Almaguer OS, Leyva Rodriguez A. Clinical profile of cardiovascular diseases in pregnant women treated in a specialized clinic. CCM [Internet]. 2025 Oct. 17 [cited 2025 Oct. 20];29:e5494. Available from: https://revcocmed.sld.cu/index.php/cocmed/article/view/5494

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ORIGINAL ARTICLES