El papel del inositol en la regulación hormonal y la reducción de la formación de quistes ováricos
Keywords:
Inositol, Polycystic Ovary Syndrome, Hormonal regulation, Ovulation, Insulin resistance.Abstract
Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age, characterized by menstrual irregularities, hyperandrogenism, and polycystic ovaries. The treatment of PCOS focuses on managing symptoms and restoring normal hormonal function. Inositol, a compound that regulates various metabolic processes, has shown promise in improving hormonal and clinical parameters in women with PCOS. Recent research suggests that inositol, particularly in its mio-inositol form, can improve ovulation, regulate menstrual cycles, and reduce testosterone levels. Furthermore, an improvement in insulin resistance, a common factor in PCOS, has been observed. Therefore, inositol use is an effective therapeutic alternative, especially for women seeking to conceive or control symptoms of this condition.
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Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Hum Reprod. 2020;33(9):1602–18. https://www.asrm.org/practice-guidance/practice-committee-documents/recommendations-from-the-2023-international-evidence-based-guideline-for-the-assessment-and-management-of-polycystic-ovary-syndrome/
Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, et al. Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Reprod Biol Endocrinol [Internet]. 2023;21(1):10. Disponible en: http://dx.doi.org/10.1186/s12958-023-01055-z
López DZD. Los inositoles como tratamiento no hormonal en el síndrome de ovario poliquístico: 5 aspectos clave [Internet]. Medscape. 2023 [citado el 01 de enero de 2025]. Disponible en: https://espanol.medscape.com/verarticulo/5910531?form=fpf
Banaszewska B, Mędraś M, Kocot J, Chudzicka-Strugała I, Malinowski B. Effect of inositol supplementation on metabolic and hormonal parameters in women with polycystic ovary syndrome: a systematic review and meta-analysis. Ginekol Pol. 2021;92(4):277-285.
Ginecología y Obstetricia de México. vol. 89. Nieto Editores; 2021. https://www.scielo.org.mx/scielo.php?pid=S0300-90412021000300006&script=sci_arttext&utm_source=
Unfer V, Facchinetti F, Orrù B, Giordani B, Nestler J. Efectos del mioinositol en mujeres con SOP: un metaanálisis de ensayos controlados aleatorizados. Endocrine Connections. 2017;6(8):647-658. Recuperado el 9 de febrero de 2025 de https://doi.org/10.1530/EC-17-0243
Showell MG, Mackenzie-Proctor R, Jordan V, Hodgson R, Farquhar C. Inositol for subfertile women with polycystic ovary syndrome. Cochrane Libr [Internet]. 2018 [citado el 9 de febrero de 2025];2018(12). Disponible en: https://www.cochrane.org/es/CD012378/MENSTR_inositol-para-las-pacientes-con-diagnostico-de-sindrome-de-ovario-poliquistico-y-subfertilidad
Prabhakar P, Mahey R, Gupta M, Khadgawat R, Kachhawa G, Sharma JB, et al. Impact of myoinositol with metformin and myoinositol alone in infertile PCOS women undergoing ovulation induction cycles: randomized controlled trial. Gynecol Endocrinol. 2020;36(5):398–401. Disponible en: https://doi.org/10.1080/09513590.2018.1549656
Mendoza N, Galan MI, Molina C, Mendoza-Tesarik R, Conde C, Mazheika M, et al. High dose of d-chiro-inositol improves oocyte quality in women with polycystic ovary syndrome undergoing ICSI: a randomized controlled trial. Gynecol Endocrinol [Internet]. 2019;36(5):398–401. Disponible en: http://dx.doi.org/10.1080/09513590.2019.1681959
Peña GM, Carballo HO-0002-3815-0675 GO, Alzugaray HO-0002-0027-2044 MG, Gámez HO-0003-2590-4367 MC, Martínez HO-0001-8095-8574 KR. Guía consensada por la Sociedad Cubana de Endocrinología para el diagnóstico y tratamiento del síndrome de ovario poliquístico Guía concertada por la Sociedad Cubana de Endocrinología para el diagnóstico y tratamiento del síndrome de ovario poliquístico [Internet]. Sld.cu. [citado el 14 de marzo de 2025]. Disponible en: https://revendocrinologia.sld.cu/index.php/endocrinologia/article/download/346/366/2583
Wojciechowska A, Osowski A, Jóźwik M, Górecki R, Rynkiewicz A, Wojtkiewicz J. La importancia de los inositoles en la mejora del perfil endocrino-metabólico en el síndrome de ovario poliquístico. Int J Mol Sci [Internet]. 2019;20(22):5787. Disponible en: http://dx.doi.org/10.3390/ijms20225787
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Copyright (c) 2025 Sylvia del Pilar Nuñez Arroba, Emilia Deyaneira Cedeño Bustos , Melanie Estefania Guanatagsi Rojas, Karen Justine Ocampo Vilema
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