Chronic inflammatory demyelinating polyradiculoneuropathy. Diagnostic difficulties
Abstract
Introduction: Chronic inflammatory demyelinating polyradiculoneuropathy is an immune-mediated neurological disorder characterized by progressive or recurrent demyelination of peripheral nerves. Although it is a rare disease, its impact on patients' quality of life is significant.
Objective: To update the clinical, diagnostic and therapeutic aspects of chronic inflammatory demyelinating polyradiculoneuropathy.
Method: A bibliographic search was carried out in Pubmed, SciELO, SCOPUS and Cochrane databases, from which 57 articles were obtained and listed in a database of Zotero bibliographic manager. After eliminating duplicate references and selecting the most relevant ones, 25 remained.
Development: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is characterized by progressive weakness and sensory loss, often affecting patients' ability to walk and perform activities of daily living independently, which may progress to respiratory paralysis. Diagnosis is based on clinical suspicion, clinical findings and demonstration of demyelinating changes on diagnostic tests. Approximately 70% of patients progress satisfactorily, but recovery becomes more difficult as time progresses. Therapy with intravenous immunoglobulin (IVIG), corticosteroids (CCs) and plasma exchange (PE) has been used.
Conclusions: Chronic inflammatory demyelinating polyradiculoneuropathy is a complex disease that requires a multidisciplinary approach for diagnosis and treatment. Specific biomarkers and specific therapeutics are not yet available, this depends on an accurate diagnosis.
Keywords: polyradiculoneuropathy, demyelinating disease, inflammation, immunoglobulin, corticosteroids, peripheral neuropathyDownloads
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