Periodontal status in relation to serum estradiol and progesterone levels in pregnant women
Keywords:
enfermedad periodontal, hormonas sexuales esteroideas, embarazoAbstract
Introduction: Understanding the impact of hormonal changes in pregnancy for the onset and evolution of periodontal disease, constitutes an important link in the development of therapeutic approaches for pregnant women.
Objective: To determine the relationship between periodontal status and serum estradiol and progesterone levels in pregnant women.
Method: A cross-sectional, analytical study in 55 pregnant women belonging to Manuel Díaz Legrá Health Area of Holguín province, was carried out between January and June 2021. Periodontal status was determined by grouping codes of the revised WHO Russell's Periodontal Index. The serum levels of estradiol and progesterone were obtained by in vitro immunological examination of electrochemiluminescence. Analysis of the relationship between variables was established by Kruskal Wallis and Mann Whitney U tests. The percentage of error tolerated was 5 %.
Results: Relationship of periodontal status between healthy pregnant women, with gingivitis or with periodontitis according to serum levels of estradiol (p=0.051) and progesterone (p=0.050) hormones. There were statistically significant differences between pregnant women with periodontitis and gingivitis with respect to estradiol (p=0.016) and progesterone (p=0.019) levels.
Conclusions: There was no correlation between the different periodontal conditions and the serum estradiol and progesterone levels in pregnant women; however, among the affected women, there was a correspondence between the lowest hormone levels and those with destruction in the deep tissues of the periodontium.
Keywords: periodontal disease, sex hormones, pregnancy.Downloads
References
Fajardo Puig ME, Rodríguez Reyes O, Berenguer Gouarnaluses MC, Berenguer Gouarnaluses JA. Folleto complementario hormonas sexuales femeninas y su relación con la enfermedad periodontal. I Jornada Virtual de Estomatología 2022. Clínica Estomatológica Docente “Dr. Luis Paéz Alfonso”. Ciego de Ávila, Cuba: 2022, febrero 22 al 28. Disponible en:
https://estocavila2021.sld.cu/index.php/estocavila/2022/paper/view/338
Gil Montoya JA, Rivero Blanco T, Leon Rios X, Expósito Ruiz M, Perez Castillo I, Aguilar Cordero MJ. Oral and General Health Conditions Involved in Periodontal Status During Pregnancy: a Prospective Cohort Study. Arch Gynecol Obstet.2022[citado 12/09 /2023];308(6). Disponible en:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10579146/pdf/404_2022_Article_6843.pdf
Rie M. Estradiol: valores normales para quedar embarazada. ONsalus. Barcelona. [Actualizado 6 sept 2024]; [citado 24 febrero 2024]. Disponible en:
https://www.onsalus.com/estradiol-valores-normales-para-quedar-embarazada-19971.html
Rivera Lugo I, Martínez Díaz M, Hernández Suárez Y, Martínez Díaz M, García Hernández Y. Prevalencia de la enfermedad periodontal en el embarazo. Rev Ciencias Médicas. 2022. [citado 17/05/2023];26(4). Disponible en:
https://revcmpinar.sld.cu/index.php/publicaciones/article/view/5494/49106
Nannan M, Xiaoping L, Ying J. Periodontal disease in pregnancy and adverse pregnancy outcomes: Progress in related mechanisms and management strategies. Front Med 2022. [citado 12/03/2023];9:963956. Disponible en:
https://pmc.ncbi.nlm.nih.gov/articles/PMC9640773/pdf/fmed-09-963956.pdf
Piaopiao Ch, Feiruo H, Xuefen Y. Prevalence of periodontal disease in pregnancy: A systematic review and meta-analysis. J Dent.2022[citado 1303 2023];125. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0300571222003098?via%3Dihub
Baudo JE, Tosti SB, Allegretti PE. Niveles séricos de Estrógenos y Progesterona en relación a la enfermedad gingival en gestantes adolescentes. Rev Intramed J. 2012 [citado 270/2021];1(3).Disponible en: http://sedici.unlp.edu.ar/handle/10915/71283
Lora MJR. Asociación entre la enfermedad periodontal y el embarazo. [Tesis]. [Santo Domingo, República Dominicana]: Universidad Iberoamericana;2021]. Disponible en:
https://repositorio.unibe.edu.do/jspui/handle/123456789/923
Murillo Zavala A, Baque Parrales GH, Chancay Sabando CJ. Prevalencia de anemia en el embarazo, tipos y consecuencias. Dom Cien. 2021[citado 17/11/2023];7(3): 549-562. Disponible en:
https://dominiodelasciencias.com/ojs/index.php/es/article/view/2010/4133
Cobas E. Safety Manual. Germany: Coba; 2008 [citado 12/05/2024]. Disponible en: https://www.manualslib.com/manual/3533609/RocheCobasE411.html?page=3#manual
Santos de Souza Massoni R, Fábio Aranha AM, Zanol Matos F, Aguirre Guedes O, Henrique Borges A, Miotto N, et al. Correlation of periodontal and microbiological evaluations, with serum levels of estradiol and progesterone, during different trimesters of gestation. Scientific Reports. 2019 [citado 13/08/2023];9(1):1762. Disponible en:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6692383/pdf/41598_2019_Article_48288.pdf
Villalta Mendoza FM, Pesántez Correa SM, González Ortega JL, Ochoa Ávila AB, Piedra Arpi CD, Reinoso Ortiz JA. Embarazo y enfermedad periodontal: Revisión de la literatura. RSD. 2022 [citado 06/08/2023];11(17). Disponible en:
http://dx.doi.org/10.33448/rsd-v11i17.39264
Mauvais Jarvis F, Klein SL, Levin ER. Estradiol, Progesterone, Immunomodulation, and COVID-19 Outcomes. Endocrinology. 2020 [citado 04/10/2024]; 161(9). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438701/
Kharah MR, Dunkel C, Carroll E, Mancuso RA, Breen EC, Okun ML, et al. Inflammatory and immune marker trajectories from pregnancy to one-year post-birth. Cytokine. 2022 [citado 12/09/2023];149(8):155758. Disponible en:
https://pubmed.ncbi.nlm.nih.gov/34773858/
Man Y, Sun L, QinJ, Zhang X, Yan S, Niu F. Exogenous progesterone short-termly affects the periodontal environment in perimenopausal women. Oral desease. Front, Endocrinol.2022[citado 12/06/ 2023]; 14:1224763. Disponible en:
https://www.semanticscholar.org/reader/0c7f3c0563c233bdb7f764677d4824be1243ea59
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